Understanding how TGFbeta affects spine development and health
Official title: TGFbeta in the pathology and development of the spine
Funded at University of Alabama at Birmingham · NIH-10881779 · Data updated 2026-11-12
This study is looking at how certain proteins affect the growth and health of the spine, using specially modified mice to see how changes in these proteins might lead to spine problems, which could help us find new ways to treat spinal conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | July 4, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $311,869 |
| NIH project number | 5R01AR078740-02 |
| Project ID | NIH-10881779 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations affecting TGFbeta signaling or those suffering from spinal disorders.
✕Less likely to help
Patients with spinal conditions unrelated to TGFbeta signaling or those without genetic predispositions may not benefit from this research.
What this research studies
This research investigates the role of TGFbeta signaling proteins in the development and maintenance of the spine. By studying genetically engineered mice, the research aims to uncover how mutations in genes that regulate TGFbeta activity can lead to spinal pathologies. The project will explore the mechanisms by which TGFbeta influences the formation of fibrous tissues in the spine and how these processes are organized during embryonic development. The findings could provide insights into regenerative strategies for spinal conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for spinal disorders by enhancing our understanding of spine development and regeneration.
How similar studies have gone: Previous studies have shown promising results in understanding TGFbeta's role in skeletal biology, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Serra, Rosa a. — University of Alabama at Birmingham
- Study coordinator: Serra, Rosa a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.