Understanding how TGFβ signaling works in the body
Structural/functional characterization of TGFβ superfamily signaling and regulation
This study is looking at how certain signaling molecules in our body work and interact with their partners, which could help us learn more about how cells communicate and how this affects our health and diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10763830 on NIH RePORTER |
What this research studies
This research investigates the TGFβ superfamily, a group of signaling molecules that play crucial roles in various biological processes. By using advanced techniques like X-ray crystallography and in vitro cellular assays, the team aims to uncover how these molecules interact with their receptors and how they can be regulated by other proteins. The goal is to better understand the mechanisms behind these interactions, which could lead to new insights into cell signaling and its implications for health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by TGFβ signaling, such as fibrosis or certain cancers.
Not a fit: Patients with conditions unrelated to TGFβ signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to TGFβ signaling dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding TGFβ signaling, indicating that this approach has potential for significant advancements.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Thompson, Thomas B — University of Cincinnati
- Study coordinator: Thompson, Thomas B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.