Understanding how TGFβ signaling affects development and cancer
The TGFÃÂÃÂÃÂò Signaling Pathway in Development and Cancer
['FUNDING_OTHER'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10890804
This study is looking at how a specific signaling pathway called TGFβ affects cell behavior in both healthy development and cancer, with the goal of finding new ways to treat cancer by understanding how TGFβ works.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10890804 on ClinicalTrials.gov |
What this research studies
This research investigates the TGFβ signaling pathway, which plays a crucial role in regulating cell behavior during development and in cancer progression. By examining how TGFβ influences cell differentiation and tumor suppression, the research aims to uncover the mechanisms behind its effects on both normal and cancerous cells. The study utilizes experimental models to explore the role of TGFβ in cancer metastasis and its interaction with epigenetic factors. Patients may benefit from insights gained into how TGFβ signaling can be targeted for therapeutic purposes.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with cancers influenced by TGFβ signaling, such as pancreatic and lung adenocarcinomas.
Not a fit: Patients with cancers unrelated to TGFβ signaling or those in advanced stages where TGFβ's role is less significant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers by targeting the TGFβ signaling pathway.
How similar studies have performed: Previous research has shown promising results in understanding TGFβ signaling in cancer, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MASSAGUE, JOAN — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: MASSAGUE, JOAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Detectable Residual Disease