Understanding how TGF-beta signaling affects the physiology of C. elegans.
Official title: TGF-beta Signaling Mechanisms in C. elegans Physiology and Homeostasis
Funded at Queens College · NIH-11056039 · Data updated 2026-11-12
This study looks at how certain signals in tiny worms called C. elegans affect their cells and overall health, which could help us understand similar processes in humans, especially related to fat metabolism and immune responses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Queens College NIH-funded |
| Lab location | 1 site (Flushing, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $376,875 |
| NIH project number | 5R35GM153390-02 |
| Project ID | NIH-11056039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals affected by conditions related to TGF-beta dysregulation, such as certain cancers or cardiovascular diseases.
✕Less likely to help
Patients with conditions unrelated to TGF-beta signaling or those not affected by the diseases being studied may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms of TGF-beta signaling in the nematode C. elegans, focusing on how these pathways influence cell function and overall organism health. By studying the interactions between different TGF-beta ligands and their receptors, the research aims to uncover how these signals can affect processes like lipid metabolism and immune responses. The approach utilizes genetic and biochemical techniques to analyze the effects of TGF-beta signaling in a simpler model organism, which may provide insights applicable to human health.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of TGF-beta signaling pathways, potentially informing new treatments for diseases like cancer and cardiovascular disorders.
How similar studies have gone: While the specific approach in C. elegans is relatively novel, previous research has shown that understanding TGF-beta signaling can lead to significant advancements in treating related diseases.
Where this research is happening
-
Queens College
Flushing, United States Active
Researchers
- Principal investigator: Savage-Dunn, Cathy — Queens College
- Study coordinator: Savage-Dunn, Cathy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.