Understanding how TGF-beta signaling affects mitochondrial function and metabolism
TGF-beta signaling in mitochondrial dynamics
['FUNDING_OTHER'] · UNIVERSITY OF ARIZONA · NIH-10976443
This study is looking at how a protein called TGF-beta affects the shape and function of tiny energy factories in our cells, which could help us understand more about adult-onset diabetes and improve health for people dealing with metabolic issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-10976443 on ClinicalTrials.gov |
What this research studies
This research investigates the role of TGF-beta signaling in regulating mitochondrial dynamics, which are crucial for maintaining cellular metabolism and function. By examining how TGF-beta influences mitochondrial shape and activity, the study aims to uncover mechanisms that could lead to better understanding of conditions like adult-onset diabetes. The research utilizes advanced biological models to explore the effects of TGF-beta on cellular processes such as proliferation and apoptosis, particularly in the context of vascular health. Patients may benefit from insights gained into how mitochondrial dysfunction contributes to metabolic diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are adults with metabolic conditions, particularly those related to obesity and diabetes.
Not a fit: Patients with metabolic disorders unrelated to mitochondrial function or those under 21 years old may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing metabolic disorders like adult-onset diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the role of TGF-beta in cellular metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, NAM Y — UNIVERSITY OF ARIZONA
- Study coordinator: LEE, NAM Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus