Understanding how TGF-beta signaling affects mitochondrial function and metabolism
Official title: TGF-beta signaling in mitochondrial dynamics
Funded at University of Arizona · NIH-10976443 · Data updated 2026-11-12
This study is looking at how a protein called TGF-beta affects the shape and function of tiny energy factories in our cells, which could help us understand more about adult-onset diabetes and improve health for people dealing with metabolic issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | February 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $329,725 |
| NIH project number | 5R35GM148171-03 |
| Project ID | NIH-10976443 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are adults with metabolic conditions, particularly those related to obesity and diabetes.
✕Less likely to help
Patients with metabolic disorders unrelated to mitochondrial function or those under 21 years old may not receive benefit from this research.
What this research studies
This research investigates the role of TGF-beta signaling in regulating mitochondrial dynamics, which are crucial for maintaining cellular metabolism and function. By examining how TGF-beta influences mitochondrial shape and activity, the study aims to uncover mechanisms that could lead to better understanding of conditions like adult-onset diabetes. The research utilizes advanced biological models to explore the effects of TGF-beta on cellular processes such as proliferation and apoptosis, particularly in the context of vascular health. Patients may benefit from insights gained into how mitochondrial dysfunction contributes to metabolic diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing metabolic disorders like adult-onset diabetes.
How similar studies have gone: Previous research has shown promising results in understanding the role of TGF-beta in cellular metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Lee, Nam Y — University of Arizona
- Study coordinator: Lee, Nam Y
Related research
Other NIH-funded projects on the same topics.
-
Retinal signals in early diabetes and how they affect vision
This grant looks at how diabetes changes the signals in the retina that control vision, with a focus on inner retinal cells and how these changes may lead to vision problems.
-
Mining safety training that connects research to practice for Western miners
A patient-facing overview of a U.S. mining safety program that partners universities and mining operators to improve training, safety practices, and outcomes for mine workers in the Western United States.
-
Developing small molecules to treat TDP-43 related brain diseases
A potential new drug candidate (XL20) for diseases like Alzheimer’s and other dementias linked to TDP-43 protein problems is being developed and refined for people who live with these conditions.
-
Mobile platform using AI to screen for oral cancer in low-resource communities
A low-cost, AI-powered mobile tool helps frontline healthcare workers screen for oral cancer and triage patients in communities with limited access to specialists.
-
A new optical method to image skin cancers using synthetic waves
A small grant is funding the development and testing of tissue-mimicking skin phantoms to improve non-invasive imaging of skin cancers.
-
MRI-guided precision care for infants with cleft palate
We’re exploring how MRI can help tailor early care for babies with cleft palate to support better speech outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.