Understanding how TGF-Beta signaling affects craniofacial fibrous dysplasia
Official title: Elucidating the Role of TGF-Beta Signaling in Craniofacial Fibrous Dysplasia of the Bone
Funded at Northern California Institute/res/edu · NIH-11058134 · Data updated 2026-11-12
This study is looking into craniofacial fibrous dysplasia, a condition that causes unusual bone growth and can affect your vision and hearing, to find out how certain signals in your body might help us discover new treatments for people dealing with this challenging issue.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 24, 2024 |
| Project end | September 23, 2026 |
| Funding year | 2024 |
| Award (this year) | $306,600 |
| NIH project number | 1R03DE033746-01A1 |
| Project ID | NIH-11058134 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with craniofacial fibrous dysplasia or those with related conditions such as McCune-Albright Syndrome.
✕Less likely to help
Patients with fibrous dysplasia affecting other skeletal regions without craniofacial involvement may not benefit from this specific research.
What this research studies
This research investigates craniofacial fibrous dysplasia (CFD), a condition that causes abnormal bone growth and can lead to serious complications like vision loss and hearing impairment. The study aims to explore the role of TGF-Beta signaling pathways in the disease, using advanced techniques such as single cell RNA sequencing to analyze affected bone tissues. By identifying the molecular mechanisms involved, the research seeks to uncover potential therapeutic targets that could lead to new treatment options for patients suffering from this debilitating condition.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments for craniofacial fibrous dysplasia, improving the quality of life for affected patients.
How similar studies have gone: Previous research has shown promise in targeting signaling pathways in similar conditions, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Wentworth, Kelly Lee — Northern California Institute/res/edu
- Study coordinator: Wentworth, Kelly Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.