Understanding how TGFβ affects immune responses in allergic diseases
TGFβ Restricts Tfh2 Differentiation but Augments IgE-Mediated Mast Cell Function: Critical and Opposing Roles in Allergic Disease
['FUNDING_OTHER'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11032247
This study is looking at how a specific protein called TGFβ affects certain immune cells and their role in allergies, especially in people with Loeys-Dietz Syndrome, to help find better ways to treat allergic reactions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11032247 on ClinicalTrials.gov |
What this research studies
This research investigates the role of TGFβ, a cytokine involved in immune regulation, in the differentiation of T follicular helper cells (Tfh) and the function of mast cells (MC) in allergic diseases. By studying patients with Loeys-Dietz Syndrome, who are prone to allergies, the research aims to uncover how disruptions in TGFβ signaling influence IgE production and allergic responses. The approach includes analyzing patient samples and using mouse models to explore the underlying mechanisms of allergic reactions. This could lead to new therapeutic targets for treating allergies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Loeys-Dietz Syndrome who experience allergies such as asthma, eczema, or food allergies.
Not a fit: Patients without Loeys-Dietz Syndrome or those not suffering from allergic diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for patients suffering from allergic diseases.
How similar studies have performed: Other research has shown promising results in understanding immune responses related to TGFβ, indicating that this approach has potential for success.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAQUE, TAMARA TASMIA — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: HAQUE, TAMARA TASMIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Allergic Disease