Understanding how TGFβ affects immune responses in allergic diseases
Official title: TGFβ Restricts Tfh2 Differentiation but Augments IgE-Mediated Mast Cell Function: Critical and Opposing Roles in Allergic Disease
Funded at Indiana University Indianapolis · NIH-11032247 · Data updated 2026-11-12
This study is looking at how a specific protein called TGFβ affects certain immune cells and their role in allergies, especially in people with Loeys-Dietz Syndrome, to help find better ways to treat allergic reactions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | June 18, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $162,000 |
| NIH project number | 1K22AI187413-01 |
| Project ID | NIH-11032247 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with Loeys-Dietz Syndrome who experience allergies such as asthma, eczema, or food allergies.
✕Less likely to help
Patients without Loeys-Dietz Syndrome or those not suffering from allergic diseases may not benefit from this research.
What this research studies
This research investigates the role of TGFβ, a cytokine involved in immune regulation, in the differentiation of T follicular helper cells (Tfh) and the function of mast cells (MC) in allergic diseases. By studying patients with Loeys-Dietz Syndrome, who are prone to allergies, the research aims to uncover how disruptions in TGFβ signaling influence IgE production and allergic responses. The approach includes analyzing patient samples and using mouse models to explore the underlying mechanisms of allergic reactions. This could lead to new therapeutic targets for treating allergies.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for patients suffering from allergic diseases.
How similar studies have gone: Other research has shown promising results in understanding immune responses related to TGFβ, indicating that this approach has potential for success.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Haque, Tamara Tasmia — Indiana University Indianapolis
- Study coordinator: Haque, Tamara Tasmia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.