Understanding how Tet1 affects intestinal stem cells
Official title: Determining the role of Tet1 in facultative intestinal stem cells
Funded at Emory University · NIH-11057710 · Data updated 2026-11-12
This study is looking at how a protein called Tet1 helps the stem cells in your intestines heal after they get hurt, especially from treatments like chemotherapy, to find better ways to support recovery for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31DK136254-03 |
| Project ID | NIH-11057710 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have undergone chemotherapy or radiation therapy and are experiencing intestinal damage.
✕Less likely to help
Patients who have not received cancer treatment or do not have intestinal health issues may not benefit from this research.
What this research studies
This research investigates the role of Tet1, a protein involved in gene regulation, in the behavior of intestinal stem cells that help maintain the health of the intestinal lining. It focuses on how these stem cells can regenerate after injury, which is often caused by cancer treatments like chemotherapy. By examining the genetic mechanisms behind this regeneration, the research aims to uncover how to better support the healing process in patients who have experienced damage to their intestinal cells. The study employs advanced techniques to analyze gene expression and cellular changes in response to injury.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance the recovery of intestinal health in cancer patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of genetic factors in stem cell regeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Janto, Nicolas Vaughan — Emory University
- Study coordinator: Janto, Nicolas Vaughan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.