Understanding how TET enzymes regulate gene activity and their role in cancer.
Official title: Molecular Mechanism of TET-mediated Gene Regulation
Funded at Ohio State University · NIH-10907662 · Data updated 2026-11-12
This study is looking at how certain enzymes help control DNA changes that can affect gene activity, which is important for preventing diseases like cancer, especially in children.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $383,265 |
| NIH project number | 5R35GM151110-02 |
| Project ID | NIH-10907662 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with childhood cancers or genetic predispositions to hematological cancers.
✕Less likely to help
Patients with cancers unrelated to DNA methylation or those without genetic predispositions may not benefit from this research.
What this research studies
This research investigates the role of TET enzymes in DNA demethylation, a crucial process for maintaining proper gene regulation and preventing diseases like cancer. By using advanced techniques to manipulate and monitor epigenetic modifications, the research aims to uncover how TET enzymes influence chromatin accessibility and gene expression. The study focuses on understanding the interactions between TET enzymes and histones, as well as the effects of temporary changes to the epigenome. This work could provide insights into the mechanisms behind childhood cancers and other disorders linked to DNA methylation.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers associated with abnormal DNA methylation.
How similar studies have gone: Previous research has shown promising results in understanding the role of epigenetic modifications in cancer, indicating that this approach has potential for success.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Lio, Jerry Chan-Wang — Ohio State University
- Study coordinator: Lio, Jerry Chan-Wang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.