Understanding how Tet enzymes influence blood cell development from endothelial cells
Official title: Role of Tet enzymes in embryonic hematopoiesis
Funded at Albert Einstein College of Medicine · NIH-11042732 · Data updated 2026-11-12
This study is looking at how certain enzymes help turn blood vessel cells into blood cells during early development, which could help us understand blood disorders better and find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $499,338 |
| NIH project number | 5R01HL172730-02 |
| Project ID | NIH-11042732 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old who may be affected by blood disorders or are interested in the biological mechanisms of blood cell development.
✕Less likely to help
Patients with established blood disorders that are not related to the mechanisms being studied may not benefit from this research.
What this research studies
This research investigates the role of Tet enzymes in the formation of blood cells from endothelial cells during embryonic development. It aims to uncover the molecular mechanisms that guide the transition of endothelial cells into blood-forming stem and progenitor cells. By utilizing mouse models, the researchers will manipulate the expression of Tet enzymes to observe their effects on blood cell specification. This work could provide insights into how blood disorders may arise and how they can be treated.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating blood disorders by enhancing our understanding of blood cell formation.
How similar studies have gone: While the specific role of Tet enzymes in blood cell development is still being explored, similar research has shown promise in understanding the genetic and epigenetic factors involved in hematopoiesis.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Dawlaty, Meelad — Albert Einstein College of Medicine
- Study coordinator: Dawlaty, Meelad
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.