Understanding how TET enzymes affect genes in cancer
Molecular Mechanism of TET-mediated Gene Regulation
This research explores how special enzymes called TET work to control our genes, which could help us understand and treat cancers, especially childhood cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11141101 on NIH RePORTER |
What this research studies
Our bodies use a process called DNA methylation to turn genes on and off, but when this process goes wrong, it can lead to diseases like cancer. TET enzymes are crucial for correcting these methylation errors and ensuring our genes function properly. This project aims to uncover exactly how TET enzymes help create a healthy environment for genes to be active. By learning more about these fundamental processes, we hope to find new ways to target the causes of cancer.
Who could benefit from this research
Good fit: This foundational research is relevant for patients with various cancers, particularly those with childhood cancers or conditions linked to TET enzyme issues.
Not a fit: Patients seeking immediate new treatments will not directly benefit from this basic science research, as it focuses on fundamental biological mechanisms.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how cancers develop and potentially inspire new treatments that correct genetic errors.
How similar studies have performed: Other studies have shown the importance of TET enzymes in cell development and their link to cancer, but the precise ways they control gene activity are still being discovered.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Lio, Jerry Chan-Wang — Ohio State University
- Study coordinator: Lio, Jerry Chan-Wang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.