Understanding how TET enzymes affect brain stem cells
Epigenetic regulation of neural stem cell biology by Tet DNA dioxygenases
['FUNDING_FELLOWSHIP'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11099795
This study is looking at how certain enzymes affect brain stem cells and their role in brain development, which could help us understand and improve conditions related to brain health for patients.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11099795 on ClinicalTrials.gov |
What this research studies
This research investigates the role of TET enzymes in regulating neural stem cells (NSCs) and their impact on brain development. By studying how these enzymes influence DNA modifications, the research aims to uncover their essential functions in maintaining the health and multipotency of NSCs. The approach involves creating specific NSC lines to observe changes in gene expression and cell behavior, which could provide insights into neurodevelopmental disorders. Patients may benefit from a better understanding of conditions related to brain development and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental syndromes or related conditions, particularly those with craniofacial abnormalities or intellectual disabilities.
Not a fit: Patients with conditions unrelated to neurodevelopment or those not affected by stem cell biology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into neurodevelopmental disorders and potential therapeutic strategies.
How similar studies have performed: Other research has shown promising results in understanding the role of epigenetic factors in neurodevelopment, suggesting that this approach could yield valuable insights.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MACARTHUR, IAN CAMPBELL — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: MACARTHUR, IAN CAMPBELL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.