Understanding how temperature and certain compounds affect pain perception through a specific channel in the body
Mechanisms of TRPV1 channel gating and modulation by temperature and vanilloids
['FUNDING_OTHER'] · UNIVERSITY OF TEXAS AT AUSTIN · NIH-10674794
This study is looking at a special part of our body that helps us feel pain, especially from heat and certain substances, to find out how it works and how we can improve pain relief for people who need it.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS AT AUSTIN (nih funded) |
| Locations | 1 site (AUSTIN, UNITED STATES) |
| Trial ID | NIH-10674794 on ClinicalTrials.gov |
What this research studies
This research investigates the TRPV1 channel, which plays a crucial role in how we perceive pain, especially in response to heat and certain chemical compounds. The project aims to uncover the mechanisms that control the opening and closing of this channel, which is essential for understanding pain signaling. By identifying the specific regions of the TRPV1 channel that are involved in its gating, and how temperature and vanilloids influence this process, the research could lead to better pain management strategies. The findings may also provide insights into how analgesic drugs can be optimized for effectiveness.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic pain conditions, particularly those related to heat sensitivity or inflammatory responses.
Not a fit: Patients with pain conditions unrelated to TRPV1 channel activity or those not experiencing significant heat-related pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain relief treatments that are more effective and have fewer side effects.
How similar studies have performed: Previous research has shown promising results in understanding TRP channels and their role in pain signaling, indicating that this approach has potential for significant advancements.
Where this research is happening
AUSTIN, UNITED STATES
- UNIVERSITY OF TEXAS AT AUSTIN — AUSTIN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JARA OSEGUERA, ANDRES — UNIVERSITY OF TEXAS AT AUSTIN
- Study coordinator: JARA OSEGUERA, ANDRES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.