Understanding how telomeres stay together in human cells
Official title: Mechanisms of Telomere Cohesion - Equipment Supplement
Funded at New York University School of Medicine · NIH-11100494 · Data updated 2026-11-12
This study is looking at how certain proteins help keep the protective ends of our chromosomes, called telomeres, working properly, which is important for understanding aging and cancer, and it involves testing both normal and cancer cells to see how these proteins behave.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 11, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $40,352 |
| NIH project number | 3R35GM149355-02S1 |
| Project ID | NIH-11100494 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cellular aging or cancer, as well as healthy volunteers for comparison.
✕Less likely to help
Patients with acute conditions unrelated to cellular aging or cancer may not receive direct benefits from this research.
What this research studies
This research focuses on the mechanisms that help maintain the cohesion of telomeres, which are protective caps at the ends of chromosomes in human cells. By utilizing various human cell lines, including both normal and cancerous cells, the research aims to identify the proteins involved in establishing and resolving telomere cohesion. The study employs advanced techniques, including the use of lentiviruses to manipulate protein levels in these cell lines, and relies on a cryogenic storage system to preserve these samples for long-term analysis. The findings could provide insights into cellular aging and cancer biology.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cellular aging and cancer, potentially informing new therapeutic strategies.
How similar studies have gone: Previous research has shown promising results in understanding telomere dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Smith, Susan — New York University School of Medicine
- Study coordinator: Smith, Susan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.