Understanding how telomeres protect chromosomes and their role in diseases.
Unraveling the Telomere Black Box: A New Single-Molecule Approach to Define the Telomere Chromatin Landscape and its Functional Mechanisms
This study is looking at the protective ends of our chromosomes, called telomeres, to understand how they work and how they might be linked to diseases like cancer and aging, with the hope that what we learn could help develop new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10471552 on NIH RePORTER |
What this research studies
This research investigates the complex structures at the ends of chromosomes called telomeres, which play a crucial role in protecting our DNA. By using advanced techniques, the study aims to uncover how telomeres function and how their regulation can impact diseases like cancer and premature aging. The research focuses on the interactions between proteins and DNA at the telomeres, which have been difficult to study due to their repetitive nature. Patients may benefit from insights gained about telomeres that could lead to new treatments or preventive strategies for related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with cancers or premature aging syndromes.
Not a fit: Patients with non-malignant conditions unrelated to telomere dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for cancer and conditions related to premature aging.
How similar studies have performed: Previous research has shown promising results in understanding telomere biology, but this approach is innovative and aims to provide deeper insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Lim, Ci Ji — University of Wisconsin-Madison
- Study coordinator: Lim, Ci Ji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.