Understanding how telomeres protect chromosomes and their role in cancer
Molecular interactions and regulatory events in telomere maintenance
This study is looking at how certain proteins help keep the ends of our chromosomes safe and healthy, which is important for preventing issues like cancer, and it's for anyone interested in understanding how our genes can affect our health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11132994 on NIH RePORTER |
What this research studies
This research investigates the molecular interactions and regulatory events involved in telomere maintenance, focusing on how telomeres protect chromosome ends from damage and ensure proper DNA replication. The study examines the role of specific proteins, such as POT1 and TPP1, in maintaining telomere integrity and their implications in various disorders, particularly cancer. By analyzing genetic variations in telomere-binding proteins, the research aims to uncover how these changes contribute to genome instability and disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cancer or those with genetic predispositions to telomere-related disorders.
Not a fit: Patients without any genetic predisposition to telomere dysfunction or those not diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer mechanisms and potential therapeutic targets for improving cancer treatment.
How similar studies have performed: Previous research has shown promising results in understanding telomere biology and its implications in cancer, indicating that this approach is built on established findings.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Taylor, Derek James — Case Western Reserve University
- Study coordinator: Taylor, Derek James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.