Understanding how telomeres protect chromosomes and their role in cancer
Official title: Molecular interactions and regulatory events in telomere maintenance
Funded at Case Western Reserve University · NIH-11132994 · Data updated 2026-11-12
This study is looking at how certain proteins help keep the ends of our chromosomes safe and healthy, which is important for preventing issues like cancer, and it's for anyone interested in understanding how our genes can affect our health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 10, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $422,899 |
| NIH project number | 5R01GM154832-02 |
| Project ID | NIH-11132994 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cancer or those with genetic predispositions to telomere-related disorders.
✕Less likely to help
Patients without any genetic predisposition to telomere dysfunction or those not diagnosed with cancer may not benefit from this research.
What this research studies
This research investigates the molecular interactions and regulatory events involved in telomere maintenance, focusing on how telomeres protect chromosome ends from damage and ensure proper DNA replication. The study examines the role of specific proteins, such as POT1 and TPP1, in maintaining telomere integrity and their implications in various disorders, particularly cancer. By analyzing genetic variations in telomere-binding proteins, the research aims to uncover how these changes contribute to genome instability and disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer mechanisms and potential therapeutic targets for improving cancer treatment.
How similar studies have gone: Previous research has shown promising results in understanding telomere biology and its implications in cancer, indicating that this approach is built on established findings.
Where this research is happening
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Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Taylor, Derek James — Case Western Reserve University
- Study coordinator: Taylor, Derek James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.