Understanding how telomeres maintain their length and function
Molecular Mechanisms of Telomere Length Homeostasis
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11046566
This study is looking at how certain proteins help keep the ends of our DNA, called telomeres, healthy and the right length, which is important for preventing aging too soon and reducing the risk of cancer, and it could lead to new ways to tackle age-related illnesses.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11046566 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms that regulate telomere length, which is crucial for maintaining genome integrity and preventing premature aging or cancer. By studying the shelterin complex and its interactions with telomerase, the research aims to uncover how these components work together to control telomere extension and stability. The approach involves detailed biochemical and structural analyses to gain insights at the atomic level, which could lead to new strategies for addressing age-related diseases and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing age-related disorders or those with a family history of cancer linked to telomere dysfunction.
Not a fit: Patients with conditions unrelated to telomere length or function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance telomere function, potentially improving health outcomes for patients with aging-related diseases and cancers.
How similar studies have performed: Previous research has shown promising results in understanding telomere biology, indicating that this area of study has the potential for significant breakthroughs.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QIAO, FENG — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: QIAO, FENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: aging associated disease, aging associated disorders, aging related disease, aging related disorders, cancer cell