Understanding how telomeres and telomerase affect aging and cancer
Telomere and telomerase evolution in S. cerevisiae
This study is looking at how tiny parts of our cells called telomeres and an enzyme called telomerase affect aging and cancer, using yeast to see how certain genetic changes can make telomeres longer and possibly improve cell health.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Morehead State University NIH-funded |
| Lab location | 1 site (Morehead, United States) |
| Project ID | NIH-10359979 on NIH RePORTER |
What this research studies
This research investigates the role of telomeres, the protective caps on chromosomes, and the enzyme telomerase in aging and cancer. By using the yeast Saccharomyces cerevisiae, researchers will explore how mutations in telomerase RNA can lead to longer telomeres and potentially impact cell division and health. The study aims to identify specific genetic changes that enhance telomerase activity, which could provide insights into the biological mechanisms of aging and cancer development. Through genetic manipulation, the research seeks to understand the evolutionary aspects of these cellular components.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of aging and cancer, particularly those with a family history of these conditions.
Not a fit: Patients with conditions unrelated to telomere biology or those not interested in genetic research may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing aging and cancer by targeting telomere and telomerase functions.
How similar studies have performed: Previous research has shown promising results in understanding telomere biology and its implications for health, indicating that this approach has potential for significant findings.
Where this research is happening
Morehead, United States
- Morehead State University — Morehead, United States (Active)
Researchers
- Principal investigator: Mefford, Melissa Anne — Morehead State University
- Study coordinator: Mefford, Melissa Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.