Understanding how telomere problems affect gut stem cells
Official title: Investigating the role of telomere failure on intestinal stem cell niche function
Funded at University of Pennsylvania · NIH-10913996 · Data updated 2026-11-12
This study looks at how problems with telomeres, which are protective caps on our DNA, affect the gut health of people with dyskeratosis congenita, a genetic condition that can cause digestive issues, and aims to find ways to help improve their intestinal health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31DK134073-02 |
| Project ID | NIH-10913996 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with dyskeratosis congenita or other conditions associated with telomere dysfunction and gastrointestinal issues.
✕Less likely to help
Patients without telomere dysfunction or gastrointestinal disorders may not benefit from this research.
What this research studies
This research investigates the impact of telomere dysfunction on the function of intestinal stem cells, particularly in patients with dyskeratosis congenita, a genetic disorder that leads to various health issues including gastrointestinal problems. The study aims to explore how telomere failure disrupts the normal turnover of intestinal cells and affects gut barrier integrity. By examining the relationship between telomere health and the Wnt signaling pathway, which is crucial for stem cell function, the research seeks to uncover potential therapeutic strategies for improving gut health in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance intestinal health and function in patients with telomere-related disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of telomeres in various biological processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Kim, Melissa — University of Pennsylvania
- Study coordinator: Kim, Melissa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.