Understanding how telomere lengths are regulated in yeast
Mechanisms underlying chromosome specific telomere lengths in yeast
This study is looking at how the protective ends of chromosomes, called telomeres, are controlled in yeast, and it hopes to find out how different factors affect their lengths, which could help us understand more about cancer and aging in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project ID | NIH-10999415 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control the lengths of telomeres, which are protective caps on the ends of chromosomes, in yeast. By using advanced nanopore sequencing techniques, the study aims to measure telomere lengths at a very detailed level and explore how different factors, such as specific DNA sequences and RNA molecules, influence these lengths. The findings could lead to new insights into how telomere length regulation is linked to cancer and age-related diseases, potentially paving the way for innovative therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with cancer or age-related degenerative diseases linked to telomere dysfunction.
Not a fit: Patients with conditions unrelated to telomere length or those not affected by cancer or age-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancer and age-related degenerative diseases by improving our understanding of telomere biology.
How similar studies have performed: While telomere biology is a well-studied field, the specific approach of using nanopore sequencing to analyze telomere lengths in yeast is relatively novel and has not been extensively tested.
Where this research is happening
Santa Cruz, United States
- University of California Santa Cruz — Santa Cruz, United States (Active)
Researchers
- Principal investigator: Greider, Carol W — University of California Santa Cruz
- Study coordinator: Greider, Carol W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.