Understanding how telomere length is maintained in yeast cells
Spontaneous replication fork collapse regulates telomere length homeostasis in wild type yeast
This study looks at how yeast cells keep their chromosome ends, called telomeres, healthy and how problems during DNA copying can affect their length, which might help us learn more about aging and cancer, ultimately leading to better ways to treat related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project ID | NIH-10760222 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which telomeres, the protective ends of chromosomes, are maintained in yeast cells. It focuses on how spontaneous replication fork collapse can influence telomere length, utilizing advanced assays to monitor these processes. By examining the role of telomerase and specific proteins involved in DNA replication, the study aims to uncover new insights into telomere biology that could have implications for understanding cancer and aging. Patients may benefit from the findings as they could lead to new strategies for managing diseases related to telomere dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic predispositions to cancer or age-related conditions linked to telomere dysfunction.
Not a fit: Patients with conditions unrelated to telomere biology or those not exhibiting telomere-related issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into telomere maintenance that may lead to innovative treatments for cancers and age-related diseases.
How similar studies have performed: Other research has shown success in understanding telomere biology and its implications for cancer, making this study a continuation of established scientific inquiry.
Where this research is happening
La Jolla, UNITED STATES
- Salk Institute for Biological Studies — La Jolla, United States (Active)
Researchers
- Principal investigator: Karlseder, Jan — Salk Institute for Biological Studies
- Study coordinator: Karlseder, Jan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.