Understanding how telomerase and telomeres work in cells
Structural biology of telomerase and telomeres
This study is looking at how telomerase and telomeres work to keep our chromosomes healthy, which could help people with conditions like aplastic anemia and congenital dyskeratosis by leading to better treatments and understanding.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11052579 on NIH RePORTER |
What this research studies
This research investigates the structure and function of telomerase and telomeres, which are crucial for maintaining chromosome integrity. By using advanced techniques like cryo-electron microscopy and NMR spectroscopy, the study aims to uncover the mechanisms behind telomere replication and the role of specific proteins in this process. Patients may benefit from insights gained about telomere-related diseases, which can lead to improved treatments and understanding of conditions like aplastic anemia and congenital dyskeratosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to telomere dysfunction, such as aplastic anemia or congenital dyskeratosis.
Not a fit: Patients with conditions unrelated to telomere biology may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for diseases associated with telomere dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding telomere biology, indicating that this approach could yield significant insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Feigon, Juli — University of California Los Angeles
- Study coordinator: Feigon, Juli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.