Understanding how teeth develop in vertebrates
Mechanisms responsible for tooth morphogenesis in vertebrates
['FUNDING_R01'] · UNIVERSITY OF MISSISSIPPI MED CTR · NIH-11090389
This study is exploring how certain genes and a vitamin-like substance called retinoic acid affect tooth development in fish, which could help us understand dental issues like cleidocranial dysplasia in people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MISSISSIPPI MED CTR (nih funded) |
| Locations | 1 site (JACKSON, UNITED STATES) |
| Trial ID | NIH-11090389 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic and cellular mechanisms that shape tooth development in vertebrates, particularly focusing on the role of retinoic acid in this process. By using fish models, such as zebrafish, the study aims to uncover how mutations in specific genes, like Runx2, lead to dental abnormalities, including cleidocranial dysplasia. The researchers will manipulate retinoic acid levels during tooth formation to observe its effects on tooth morphology and identify new genes involved in this process. This work could provide insights into the biological signals that govern tooth development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions affecting tooth development, such as cleidocranial dysplasia.
Not a fit: Patients without genetic dental abnormalities or those who do not have a family history of such conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for dental abnormalities in humans.
How similar studies have performed: Previous research has shown success in using fish models to study genetic and developmental processes, indicating that this approach is promising.
Where this research is happening
JACKSON, UNITED STATES
- UNIVERSITY OF MISSISSIPPI MED CTR — JACKSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GIBERT, YANN — UNIVERSITY OF MISSISSIPPI MED CTR
- Study coordinator: GIBERT, YANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.