Understanding how TDP-43 contributes to Alzheimer's disease
Mechanisms of TDP-43 neurotoxicity in Alzheimer's disease
['FUNDING_OTHER'] · VA PUGET SOUND HEALTHCARE SYSTEM · NIH-10950297
This study is looking at how a protein called TDP-43, which builds up in the brains of people with Alzheimer's, interacts with other proteins to make the disease worse, and it aims to find new ways to understand and treat Alzheimer's.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VA PUGET SOUND HEALTHCARE SYSTEM (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10950297 on ClinicalTrials.gov |
What this research studies
This research investigates the role of TDP-43, a protein that forms aggregates in the brains of Alzheimer's patients, and how it interacts with other proteins like tau to worsen neurodegeneration. By using advanced models, including precision gene editing and behavioral assays in C. elegans, the study aims to uncover the mechanisms behind TDP-43's neurotoxicity. The findings could lead to a better understanding of Alzheimer's disease progression and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing symptoms of Alzheimer's disease.
Not a fit: Patients under the age of 65 or those without Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent cognitive decline in Alzheimer's patients.
How similar studies have performed: Previous research has shown that understanding protein interactions in neurodegenerative diseases can lead to significant advancements in treatment strategies.
Where this research is happening
SEATTLE, UNITED STATES
- VA PUGET SOUND HEALTHCARE SYSTEM — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIACHKO, NICOLE FARON — VA PUGET SOUND HEALTHCARE SYSTEM
- Study coordinator: LIACHKO, NICOLE FARON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.