Understanding how TCF-1 regulates CD8+ T cell development
Official title: Defining the regulation and regulatory mechanisms of TCF-1 in CD8+ T cell differentiation
Funded at Washington University · NIH-10986104 · Data updated 2026-11-12
This study is looking at how a specific protein helps certain immune cells, called CD8+ T cells, develop and respond to infections and cancer, with the goal of finding better ways to improve vaccines and cancer treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $34,926 |
| NIH project number | 5F31AI174696-03 |
| Project ID | NIH-10986104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with acute infections or cancer who may benefit from enhanced CD8+ T cell responses.
✕Less likely to help
Patients with conditions unrelated to CD8+ T cell function or those not experiencing acute infections or cancer may not benefit from this research.
What this research studies
This research investigates the role of the transcription factor TCF-1 in the differentiation of CD8+ T cells, which are essential for fighting infections and cancer. It focuses on how these cells respond differently to acute versus chronic antigen exposure, aiming to uncover the molecular mechanisms that lead to effective immune responses. By studying the pathways that lead to the formation of memory T cells and exhausted T cells, the research seeks to improve therapeutic strategies, particularly in cancer treatment. Patients may benefit from insights that could enhance vaccine efficacy and immune checkpoint therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments and vaccines by enhancing the immune system's ability to respond to tumors and infections.
How similar studies have gone: Previous research has shown promising results in understanding T cell differentiation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Murphy, Maegan — Washington University
- Study coordinator: Murphy, Maegan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.