Understanding how Tcf-1 influences T cell development
Molecular functions of Tcf-1 in DP thymocytes
This study is looking at how a protein called Tcf-1 helps T cells grow and develop in the thymus, which is important for our immune system, and it could help us understand more about immune-related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-10731369 on NIH RePORTER |
What this research studies
This research investigates the role of Tcf-1, a DNA binding protein, in the development of T cells within the thymus. It focuses on how Tcf-1 interacts with other proteins and the chromatin structure to regulate gene expression during T cell differentiation. By studying these mechanisms, the research aims to uncover the complexities of immune system development and function, which could have implications for various immune-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to T cell dysfunction or immune system disorders.
Not a fit: Patients with fully functional immune systems or those not affected by T cell-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for immune system disorders.
How similar studies have performed: Other research has shown success in understanding the roles of DNA binding proteins in immune cell development, suggesting that this approach could yield valuable insights.
Where this research is happening
Scottsdale, United States
- Mayo Clinic Arizona — Scottsdale, United States (Active)
Researchers
- Principal investigator: Gounari, Fotini — Mayo Clinic Arizona
- Study coordinator: Gounari, Fotini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.