Understanding how Tbx3 affects blood vessel growth in the retina
Official title: The role of Tbx3 in retinal angiogenesis and eye disease
Funded at Upstate Medical University · NIH-11075918 · Data updated 2026-11-12
This study is looking at how a gene called Tbx3 affects the growth of blood vessels in the eye, especially for people with conditions that can cause vision problems, like Retinopathy of Prematurity and Familial Exudative Vitreoretinopathy, to help find new ways to treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $423,246 |
| NIH project number | 5R01EY033910-02 |
| Project ID | NIH-11075918 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Retinopathy of Prematurity or Familial Exudative Vitreoretinopathy.
✕Less likely to help
Patients with retinal diseases unrelated to vascular issues may not benefit from this research.
What this research studies
This research investigates the role of the Tbx3 gene in the development of blood vessels in the retina, particularly in patients with conditions like Retinopathy of Prematurity and Familial Exudative Vitreoretinopathy. The study aims to uncover the molecular mechanisms that lead to insufficient blood vessel formation, which can result in vision problems. By examining how Tbx3 influences various cell types in the retina, the research seeks to provide insights into potential new treatments for retinal vascular diseases. The approach involves analyzing the interactions between retinal neurons and vascular cells to understand their coordination in blood vessel growth.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating vision loss associated with retinal vascular diseases.
How similar studies have gone: Other research has shown promising results in understanding the genetic factors influencing retinal angiogenesis, making this approach both relevant and potentially impactful.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Viczian, Andrea S — Upstate Medical University
- Study coordinator: Viczian, Andrea S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.