Understanding how TBX2 contributes to rhabdomyosarcoma in children
Official title: Characterization of the Regulation and Gene Targets of TBX2 in Rhabdomyosarcoma
Funded at Southern Illinois University Carbondale · NIH-10731025 · Data updated 2026-11-12
This study is looking at how a gene called TBX2 might help rhabdomyosarcoma, a type of cancer that affects kids' muscles, grow faster, and the researchers hope to find new ways to treat this cancer by understanding how TBX2 works with other genes.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Illinois University Carbondale NIH-funded |
| Lab location | 1 site (Carbondale, United States) |
| Project start | July 8, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $445,500 |
| NIH project number | 1R15CA274384-01A1 |
| Project ID | NIH-10731025 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with rhabdomyosarcoma, particularly those with aggressive subtypes of the disease.
✕Less likely to help
Patients with other types of cancer or those who do not have rhabdomyosarcoma may not benefit from this research.
What this research studies
This research investigates the role of the TBX2 gene in the development of rhabdomyosarcoma, a type of cancer that affects skeletal muscle in children. The team aims to uncover how TBX2 promotes tumor growth by inhibiting important cell growth regulators. By studying the molecular mechanisms involved, they hope to identify new therapeutic strategies that could help reduce the cancer's aggressive nature. The research involves analyzing the interactions between TBX2 and other genes that influence muscle cell differentiation and proliferation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the mechanisms driving rhabdomyosarcoma, potentially improving outcomes for affected children.
How similar studies have gone: Other research has shown promising results in targeting oncogenes like TBX2 in various cancers, suggesting that this approach could be effective in rhabdomyosarcoma as well.
Where this research is happening
-
Southern Illinois University Carbondale
Carbondale, United States Active
Researchers
- Principal investigator: Davie, Judith Kimberly — Southern Illinois University Carbondale
- Study coordinator: Davie, Judith Kimberly
Related research
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A new grant is studying why infantile rhabdomyosarcoma develops and what drugs or strategies could specifically target it in young children.
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Targeting CLK2 to Fight Rhabdomyosarcoma
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Epitranscriptomic Crosstalk in Alveolar Rhabdomyosarcoma
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.