Understanding how TBK1 and mTOR interact in the body
Official title: Regulation and function of TBK1-mTOR crosstalk
Funded at University of Michigan at Ann Arbor · NIH-11092885 · Data updated 2026-11-12
This study is looking at how two important pathways in our cells work together to manage metabolism and immune responses, which could help us find better ways to treat obesity and type II diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 19, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $408,408 |
| NIH project number | 5R01GM150679-03 |
| Project ID | NIH-11092885 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with obesity or adult-onset diabetes who may benefit from improved metabolic regulation.
✕Less likely to help
Patients who do not have metabolic disorders or obesity may not receive direct benefits from this research.
What this research studies
This research investigates the interaction between two important cellular signaling pathways, TBK1 and mTOR, which play critical roles in regulating metabolism and immune responses. By examining how TBK1 influences mTOR activity in response to various stimuli, such as nutrients and hormones, the research aims to uncover mechanisms that could lead to better understanding and treatment of conditions like obesity and type II diabetes. The approach involves both laboratory experiments and in vivo studies to gather comprehensive data on these interactions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing obesity-related conditions and improving metabolic health.
How similar studies have gone: Previous research has shown promising results in understanding the roles of mTOR in metabolism, suggesting that this investigation could build on established findings.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Fingar, Diane C. — University of Michigan at Ann Arbor
- Study coordinator: Fingar, Diane C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.