Understanding how TBC1D19 affects cell structure and signaling
Official title: Investigating the role of TBC1D19 in microtubule dynamics, ciliation and organelle morphology
Funded at New York University School of Medicine · NIH-10997705 · Data updated 2026-11-12
This study is looking at a protein called TBC1D19 to see how it helps build and maintain tiny structures in our cells called primary cilia, which play a big role in how cells grow and divide, and the findings could help us understand certain developmental disorders and cancer better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31GM156062-01 |
| Project ID | NIH-10997705 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with developmental disorders or cancers that may be associated with ciliary dysfunction.
✕Less likely to help
Patients with conditions unrelated to ciliary function or those not experiencing developmental disorders or cancers may not benefit from this research.
What this research studies
This research investigates the role of a protein called TBC1D19 in the formation and function of primary cilia, which are important cellular structures involved in signaling pathways that regulate cell growth and division. The study aims to understand how TBC1D19 influences microtubule dynamics and the morphology of organelles, which could have implications for developmental disorders and cancer. By using advanced techniques to manipulate and observe cellular processes, researchers hope to uncover the mechanisms by which TBC1D19 operates within cells.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of developmental disorders and cancers linked to ciliary defects.
How similar studies have gone: Previous research has shown success in understanding the role of cilia in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Collado, Loren — New York University School of Medicine
- Study coordinator: Collado, Loren
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.