Understanding how tau proteins are processed in cells
Core B: Macromolecular and Cellular Structure Core
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10891470
This study is looking at how tau proteins work in our cells and how they can be stabilized or broken down, with the goal of finding new ways to help people with neurodegenerative diseases like Alzheimer's.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10891470 on ClinicalTrials.gov |
What this research studies
This research focuses on the structural characterization of tau proteins and their metabolism within cells, particularly how they are stabilized and degraded. Using advanced techniques like cryo-electron microscopy, the team aims to visualize tau proteins at an atomic level and understand their interactions with other cellular components. By investigating the mechanisms of tau turnover, the research seeks to identify potential therapeutic targets for diseases related to tau dysfunction, such as neurodegenerative disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by neurodegenerative diseases, particularly those with tau pathology.
Not a fit: Patients with conditions unrelated to tau protein metabolism or those not affected by neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodegenerative diseases by targeting the processes that regulate tau protein metabolism.
How similar studies have performed: Previous research has shown promise in using cryo-electron microscopy for studying protein structures, indicating that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AGARD, DAVID A. — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: AGARD, DAVID A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.