Understanding how tau protein interacts with actin and its effects on Alzheimer's disease
Official title: Elucidating the Effects of Post-Translational Modifications on Tau Binding to F-actin and PSD95
Funded at Weill Medical Coll of Cornell Univ · NIH-10979147 · Data updated 2026-11-12
This study is looking at how a protein called tau behaves in Alzheimer's disease and how changes to tau might affect its interactions with other proteins, with the goal of finding new ways to help improve treatments for people living with Alzheimer's.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 19, 2022 |
| Project end | December 18, 2025 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31AG077836-03 |
| Project ID | NIH-10979147 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related tauopathies.
✕Less likely to help
Patients with non-tau related neurodegenerative conditions may not benefit from this research.
What this research studies
This research investigates the role of tau protein in Alzheimer's disease, particularly how it binds to actin filaments and a protein called PSD-95. The study aims to uncover the effects of various chemical modifications on tau, which may influence its interactions and contribute to neurodegeneration. By exploring these mechanisms, the research seeks to identify new therapeutic targets that could improve treatment outcomes for patients with Alzheimer's disease. The approach involves laboratory experiments to analyze tau's behavior in the presence of different post-translational modifications.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating Alzheimer's disease by targeting tau-related pathways.
How similar studies have gone: Previous research has shown promising results in understanding tau interactions, but this specific approach is relatively novel.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Mancinelli, Chiara Diamante — Weill Medical Coll of Cornell Univ
- Study coordinator: Mancinelli, Chiara Diamante
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.