Understanding how tau protein changes affect Alzheimer's and related dementias
Investigating physiological pathways modulating tau homeostasis: potential implications for Alzheimer's Disease and Related Dementia
['FUNDING_FELLOWSHIP'] · JOHNS HOPKINS UNIVERSITY · NIH-10899143
This study is looking at how changes in certain body processes affect tau protein levels, which are important for understanding Alzheimer's disease, and it hopes to find new ways to help treat patients with Alzheimer's and similar conditions.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10899143 on ClinicalTrials.gov |
What this research studies
This research investigates the physiological pathways that regulate tau protein levels, which are crucial in the development of Alzheimer's disease and related dementias. By examining how disruptions in these pathways lead to tau abnormalities, the study aims to uncover the underlying mechanisms contributing to neurodegeneration. The research utilizes biochemical and proteomic analyses of patient samples to identify potential therapeutic targets. Patients may benefit from insights gained that could lead to new treatment strategies for Alzheimer's and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, as well as those with amyotrophic lateral sclerosis (ALS).
Not a fit: Patients with non-neurodegenerative conditions or those without any form of dementia are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for Alzheimer's disease and related dementias, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding tau protein dynamics in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIMENEZ-ORNELAS, CONSUELO — JOHNS HOPKINS UNIVERSITY
- Study coordinator: JIMENEZ-ORNELAS, CONSUELO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome