Understanding how tau protein changes affect Alzheimer's and related dementias
Official title: Investigating physiological pathways modulating tau homeostasis: potential implications for Alzheimer's Disease and Related Dementia
Funded at Johns Hopkins University · NIH-10899143 · Data updated 2026-11-12
This study is looking at how changes in certain body processes affect tau protein levels, which are important for understanding Alzheimer's disease, and it hopes to find new ways to help treat patients with Alzheimer's and similar conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AG087599-01 |
| Project ID | NIH-10899143 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, as well as those with amyotrophic lateral sclerosis (ALS).
✕Less likely to help
Patients with non-neurodegenerative conditions or those without any form of dementia are unlikely to benefit from this research.
What this research studies
This research investigates the physiological pathways that regulate tau protein levels, which are crucial in the development of Alzheimer's disease and related dementias. By examining how disruptions in these pathways lead to tau abnormalities, the study aims to uncover the underlying mechanisms contributing to neurodegeneration. The research utilizes biochemical and proteomic analyses of patient samples to identify potential therapeutic targets. Patients may benefit from insights gained that could lead to new treatment strategies for Alzheimer's and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for Alzheimer's disease and related dementias, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding tau protein dynamics in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Jimenez-Ornelas, Consuelo — Johns Hopkins University
- Study coordinator: Jimenez-Ornelas, Consuelo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.