Understanding how tau protein affects memory loss in Alzheimer's disease
Impaired activity-dependent protein synthesis in dendrites and pathophysiology in tauopathy
This study is looking at how a harmful protein called tau affects brain cells' ability to connect and communicate, which is important for memory, especially in people with Alzheimer's and similar conditions, to find ways to help improve memory and brain function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project ID | NIH-10893602 on NIH RePORTER |
What this research studies
This research investigates the role of pathogenic tau protein in disrupting the ability of neurons to form connections that are essential for memory. By studying how tau inhibits the process of protein synthesis in dendrites, the research aims to uncover the molecular mechanisms that lead to memory decline in Alzheimer's disease and related dementias. The approach involves using transgenic mouse models to observe changes in synaptic plasticity, particularly focusing on long-term potentiation, which is crucial for memory formation. The ultimate goal is to identify potential therapeutic strategies that could restore synaptic function and improve memory.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias who are experiencing memory impairments.
Not a fit: Patients with early-stage cognitive decline not yet diagnosed with Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance memory function in patients with Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promising results in understanding the role of tau in Alzheimer's disease, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Novato, United States
- Buck Institute for Research on Aging — Novato, United States (Active)
Researchers
- Principal investigator: Tracy, Tara — Buck Institute for Research on Aging
- Study coordinator: Tracy, Tara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.