Understanding how Tau protein affects lung cell repair and organization
Official title: Tau Mediates Microtubule and Mitochondrial Dynamics to Control Cellular Organization and Alveolar Epithelial Repair
Funded at Duke University · NIH-11166516 · Data updated 2026-11-12
This study is looking at how a protein called Tau helps lung cells heal and stay organized, especially as we age or face other challenges, with the goal of finding new ways to improve lung health for people with conditions like pulmonary fibrosis and emphysema.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 10, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $561,220 |
| NIH project number | 5R01HL174525-02 |
| Project ID | NIH-11166516 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults or individuals with lung conditions such as COPD or pulmonary fibrosis.
✕Less likely to help
Patients with acute lung injuries unrelated to aging or chronic lung diseases may not benefit from this research.
What this research studies
This research investigates the role of Tau protein in the repair and organization of alveolar epithelial cells in the lungs, which are crucial for gas exchange. The study focuses on how aging and other factors can disrupt the normal function and replenishment of these cells after injury. By examining the mechanisms that regulate the differentiation of type-2 alveolar cells into type-1 cells, the research aims to uncover potential therapeutic targets for improving lung health, particularly in conditions like pulmonary fibrosis and emphysema.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung repair and function in patients with age-related lung diseases.
How similar studies have gone: Previous research has shown promising results in understanding cellular mechanisms related to lung repair, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Tata, Aleksandra — Duke University
- Study coordinator: Tata, Aleksandra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.