Understanding how tau protein affects cognitive decline in Alzheimer's disease across different ages
Mathematical Models of Tau-PET Measures and Cognitive Decline in Alzheimer's Disease Across the Lifespan
This study looks at how the buildup of tau protein affects thinking and memory in people with Alzheimer's as they get older, and it hopes to find out the best time to start treatments that target tau to help personalize care for patients based on their age and health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-11168846 on NIH RePORTER |
What this research studies
This research investigates the relationship between tau protein accumulation and cognitive decline in Alzheimer's disease (AD) as people age. By using advanced mathematical modeling techniques, the study aims to clarify how tau levels interact with cognitive function and how this relationship may vary with age and other biomarkers. The findings could help identify the best timing for tau-targeting therapies, which are becoming more common in AD treatment. Patients may benefit from insights that could inform personalized treatment plans based on their age and other health factors.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, particularly those at various stages of cognitive decline.
Not a fit: Patients with non-Alzheimer's forms of dementia or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective timing and strategies for tau-targeting therapies in Alzheimer's disease.
How similar studies have performed: Other research has shown promise in using mathematical modeling to understand complex biological relationships, suggesting that this approach could yield valuable insights in Alzheimer's disease.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Ackley, Sarah — Brown University
- Study coordinator: Ackley, Sarah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.