Understanding how Tau protein affects Alzheimer's disease and related disorders
Connecting nuclear functions of Tau with pathology in Alzheimer's disease and other Tauopathies
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-10875707
This study is looking at how a protein called Tau behaves in Alzheimer's disease and similar brain conditions, hoping to find new ways to help patients by understanding how Tau affects brain health and function.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-10875707 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Tau protein in Alzheimer's disease and other neurodegenerative conditions known as Tauopathies. It explores how Tau accumulates in the brain and its various functions, particularly in the nucleus of cells, where it may influence DNA protection and gene regulation. By examining the molecular mechanisms of Tau, the research aims to uncover how changes in this protein contribute to the pathology of Alzheimer's disease. Patients may benefit from insights that could lead to new therapeutic strategies targeting Tau-related processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or other Tauopathies.
Not a fit: Patients with neurodegenerative diseases not associated with Tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of Tau in neurodegenerative diseases, indicating that this approach has potential for significant findings.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRETZSCHMAR, DORIS — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: KRETZSCHMAR, DORIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease pathology, Alzheimer's disease patient