Understanding how tau and TDP-43 proteins interact in Alzheimer's disease
Official title: Novel Mechanisms of tau and TDP-43 synergy in Alzheimer's disease
Funded at University of Washington · NIH-11021825 · Data updated 2026-11-12
This study is looking at how two proteins, tau and TDP-43, work together in Alzheimer's disease to help us understand more about the condition and find better ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $757,027 |
| NIH project number | 1R01AG090551-01 |
| Project ID | NIH-11021825 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those showing rapid cognitive decline.
✕Less likely to help
Patients with other forms of dementia not related to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the complex relationship between tau and TDP-43 proteins in Alzheimer's disease, which is a leading cause of dementia affecting millions. Using advanced models, the researchers will explore how these proteins interact and affect brain function, particularly focusing on gene expression related to cellular waste management. By examining these interactions, the study aims to uncover new mechanisms that could lead to better understanding and treatment of Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow down or prevent cognitive decline in Alzheimer's patients.
How similar studies have gone: Previous research has shown promising results in understanding the roles of tau and TDP-43 in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Latimer, Caitlin Shannon — University of Washington
- Study coordinator: Latimer, Caitlin Shannon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.