Understanding how tau and TDP-43 proteins interact in Alzheimer's disease
Novel Mechanisms of tau and TDP-43 synergy in Alzheimer's disease
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11021825
This study is looking at how two proteins, tau and TDP-43, work together in Alzheimer's disease to help us understand more about the condition and find better ways to treat it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11021825 on ClinicalTrials.gov |
What this research studies
This research investigates the complex relationship between tau and TDP-43 proteins in Alzheimer's disease, which is a leading cause of dementia affecting millions. Using advanced models, the researchers will explore how these proteins interact and affect brain function, particularly focusing on gene expression related to cellular waste management. By examining these interactions, the study aims to uncover new mechanisms that could lead to better understanding and treatment of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those showing rapid cognitive decline.
Not a fit: Patients with other forms of dementia not related to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow down or prevent cognitive decline in Alzheimer's patients.
How similar studies have performed: Previous research has shown promising results in understanding the roles of tau and TDP-43 in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LATIMER, CAITLIN SHANNON — UNIVERSITY OF WASHINGTON
- Study coordinator: LATIMER, CAITLIN SHANNON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: aging associated disease, aging associated disorders