Understanding how tau and amyloid beta proteins interact in Alzheimer's disease
Official title: Deciphering tau phosphorylation and Abeta/tau strain interactions in Alzheimer’s pathogenesis
Funded at University of Florida · NIH-11100004 · Data updated 2026-11-12
This study is looking at how two proteins, tau and amyloid beta, work together to cause problems in the brain that lead to Alzheimer's disease, and it hopes to find new ways to help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 30, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $441,739 |
| NIH project number | 5R01AG078734-04 |
| Project ID | NIH-11100004 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease, particularly those with early-onset familial Alzheimer's.
✕Less likely to help
Patients with Alzheimer's disease who do not have significant tau or Aβ pathology may not benefit from this research.
What this research studies
This research investigates the roles of tau and amyloid beta (Aβ) proteins in the development of Alzheimer's disease. By using mouse models, the study aims to explore how Aβ deposition can lead to tau misfolding and the formation of neurofibrillary tangles, which are associated with cognitive decline. The researchers will focus on the mechanisms that drive the interaction between these proteins and how they contribute to the progression of Alzheimer's symptoms. Patients may benefit from insights gained that could lead to new therapeutic strategies targeting these interactions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the interactions between tau and Aβ in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Chakrabarty, Paramita — University of Florida
- Study coordinator: Chakrabarty, Paramita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.