Understanding how tamoxifen affects endometrial cancer risk
Official title: Mechanisms of tamoxifen-associated endometrial cancer risk
Funded at University of Utah · NIH-10815809 · Data updated 2026-11-12
This study is looking into how tamoxifen, a common breast cancer treatment, might raise the chances of getting endometrial cancer, so we can better understand this risk and help breast cancer patients stay healthier.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $170,988 |
| NIH project number | 5R21CA270580-02 |
| Project ID | NIH-10815809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are breast cancer patients who are prescribed tamoxifen and are concerned about the associated risks.
✕Less likely to help
Patients who are not receiving tamoxifen or those without a history of breast cancer may not benefit from this research.
What this research studies
This research investigates the mechanisms by which tamoxifen, a common treatment for breast cancer, may increase the risk of endometrial cancer. The study aims to uncover how tamoxifen interacts with estrogen receptors in different tissues, particularly focusing on the endometrium. By using advanced techniques to analyze the molecular interactions involved, researchers hope to clarify the factors that contribute to this risk. This knowledge could lead to improved treatment strategies for breast cancer patients who are at risk of developing endometrial cancer.
Why it matters
Potential benefit: If successful, this research could lead to safer treatment options for breast cancer patients taking tamoxifen, reducing their risk of endometrial cancer.
How similar studies have gone: While there have been studies on tamoxifen's effects, this research aims to explore novel molecular mechanisms that have not been fully understood, making it a potentially groundbreaking investigation.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Gertz, Jason — University of Utah
- Study coordinator: Gertz, Jason
Related research
Other NIH-funded projects on the same topics.
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Prognostic tools to guide adjuvant therapy for Black women after hysterectomy for endometrial cancer
A new project aims to create and validate easy-to-use tools that help doctors tailor post-surgery treatment for Black women with endometrial cancer.
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Understanding why guideline-concordant endometrial cancer treatment varies in high-risk groups
This project looks at why some patients with endometrial cancer don’t receive care that follows national guidelines, aiming to find ways to ensure more patients get the best-supported treatments.
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Targeting hormone resistance to prevent endometrial cancer
Aims to boost progesterone’s cancer-preventing effect in the lining of the uterus to stop cancer from developing in people at risk, especially those who are obese or young.
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Inhibiting AXL to Improve Treatment Response in Endometrial Cancer
A cancer treatment study is testing whether blocking AXL with batiraxcept together with standard chemotherapy can help people with certain aggressive uterine cancers respond better.
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Targeting HSPA Proteins to Help Women with Advanced or Recurrent Endometrial Cancer
Aims to test a drug called SHetA2 that may slow or stop growth of advanced endometrial cancer by targeting cancer-friendlier proteins, with a focus on reducing treatment toxicity.
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Endometrial Cancer SPORE: New strategies to prevent and treat endometrial cancer
A multi-institution program is testing new ways to prevent and treat endometrial cancer in people, with three linked projects and multiple cores to support translational research.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.