Understanding how T cells work in fighting tuberculosis
Dissecting the molecular regulation of T cell localization and function within the Mycobacterium tuberculosis granuloma
This study is looking at how a type of immune cell called CD4 T cells helps fight tuberculosis (TB) in the lungs and how a certain molecule might change how well these cells work, with the hope of finding better ways to treat TB in people.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11001178 on NIH RePORTER |
What this research studies
This research investigates the role of CD4 T cells in the immune response to Mycobacterium tuberculosis, the bacteria that causes tuberculosis (TB). It focuses on how these T cells are localized within the lungs and how their function is affected by a signaling molecule called TGFβ. By using a mouse model of TB infection, the researchers aim to uncover mechanisms that limit T cell effectiveness and explore ways to enhance their activity against the infection. The findings may lead to improved treatment strategies for TB in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis or those at high risk of developing the disease.
Not a fit: Patients with non-infectious diseases or those not affected by tuberculosis will likely not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for tuberculosis, potentially reducing the number of new cases and deaths associated with the disease.
How similar studies have performed: Previous research has shown promising results in understanding T cell dynamics in other infectious diseases, suggesting potential for success in this area as well.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Gern, Benjamin Henry — Seattle Children's Hospital
- Study coordinator: Gern, Benjamin Henry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.