Understanding how T cells protect against infections
Official title: Regulation of T cell immunity
Funded at VA San Diego Healthcare System · NIH-11046311 · Data updated 2026-11-12
This study is looking at how a protein called Foxo1 affects memory T cells, which are important for keeping us safe from getting sick again, and it uses mice to learn more about how these cells work in different parts of the body, with hopes of improving vaccines and our understanding of the immune system.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| NIH project number | 1I01BX006818-01 |
| Project ID | NIH-11046311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of infections or those interested in vaccine responses.
✕Less likely to help
Patients who are not affected by infectious diseases or do not have a history of vaccination may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, Foxo1, in the function of memory T cells that help protect the body from reinfections. By using a mouse model, the study aims to explore how these T cells operate in different tissues and contexts. Advanced techniques will be employed to analyze the cells at a molecular level, providing insights into how Foxo1 influences their behavior. The findings could lead to improved vaccine strategies and better understanding of immune responses.
Why it matters
Potential benefit: If successful, this research could enhance vaccine development and improve immune responses against infectious diseases.
How similar studies have gone: Other research has shown promising results in understanding T cell immunity, making this approach both innovative and relevant.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Chang, John T — VA San Diego Healthcare System
- Study coordinator: Chang, John T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.