Understanding how T cells move in the body
Official title: Defining CasL as an Orchestrator of T cell Migration
Funded at Upstate Medical University · NIH-11103268 · Data updated 2026-11-12
This study is looking at how a special protein helps T cells move from the bloodstream into tissues, which is important for fighting infections and cancer, and it hopes to find new ways to boost the immune response for people with inflammatory diseases or cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | June 4, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $407,500 |
| NIH project number | 5R01AI185016-02 |
| Project ID | NIH-11103268 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve immune dysfunction, such as cancer or chronic inflammatory diseases.
✕Less likely to help
Patients with stable, non-inflammatory conditions or those not involving immune system dysfunction may not benefit from this research.
What this research studies
This research investigates the mechanisms that control how T cells migrate from blood vessels into tissues, which is essential for immune responses against infections and tumors. The study focuses on a signaling protein called CasL that plays a critical role in T cell movement by responding to mechanical signals in their environment. By manipulating the signaling pathways involved, the research aims to enhance our understanding of T cell behavior, potentially leading to new treatments for inflammatory diseases and cancer. Patients may benefit from insights gained about improving immune responses through targeted therapies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses in patients with cancer or inflammatory diseases.
How similar studies have gone: Other research has shown promising results in manipulating immune cell migration, indicating that this approach has potential for success.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Roy, Nathan H. — Upstate Medical University
- Study coordinator: Roy, Nathan H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.