Understanding how T cells interact with the immune system to fight Staphylococcus aureus infections after brain surgery
T cell-innate immune crosstalk regulates Staphylococcus aureus craniotomy infection
['FUNDING_R01'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-11044089
This study is looking at how certain immune cells called T cells help fight infections from Staphylococcus aureus after brain surgery, using mice to understand how these cells interact with bacteria that can stick around and cause problems, with the goal of finding better ways to clear these infections and help patients heal.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-11044089 on ClinicalTrials.gov |
What this research studies
This research investigates the role of T cells in managing infections caused by Staphylococcus aureus following craniotomy procedures. Using a mouse model that mimics human conditions, the study explores how T cells contribute to the persistence of bacterial biofilms on bone flaps, which can lead to complications despite antibiotic treatment. The researchers aim to uncover the mechanisms behind T cell and innate immune system interactions to develop new strategies for eradicating these biofilms and improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing craniotomy procedures who are at risk for Staphylococcus aureus infections.
Not a fit: Patients who have already experienced severe complications from craniotomy or those not undergoing this type of surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for preventing and managing infections after brain surgery.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to bacterial infections, suggesting that this approach may yield valuable insights.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIELIAN, TAMMY L — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: KIELIAN, TAMMY L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.