Understanding how T cells fight tuberculosis without needing specific antigens
Official title: The role of antigen-independent T cell activation in controlling M. tuberculosis infection
Funded at University of Washington · NIH-11126526 · Data updated 2026-11-12
This study is looking at how certain immune cells called T cells help fight tuberculosis (TB) infections, especially in adults who are more likely to get sick, to find new ways to create better vaccines against TB.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31AI179043-02 |
| Project ID | NIH-11126526 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include adults and children who are at risk of tuberculosis infection or have been exposed to the bacteria.
✕Less likely to help
Patients who are not at risk for tuberculosis or those who have already been effectively treated for the infection may not benefit from this research.
What this research studies
This research investigates the role of T cells in controlling tuberculosis (TB) infections, particularly focusing on how some T cells can be activated without specific antigens. The study aims to explore both classical T cells, which respond to peptide antigens, and nonclassical T cells, which can recognize non-peptide antigens. By examining these mechanisms, the research seeks to uncover new strategies for developing effective vaccines against TB, especially for adults who are at higher risk of pulmonary disease. Patients may be involved in studies that assess their immune responses to TB and the effectiveness of potential new vaccines.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines against tuberculosis, potentially saving lives and reducing disease transmission.
How similar studies have gone: Previous research has shown promise in understanding T cell responses to infections, but this specific approach focusing on antigen-independent activation is relatively novel.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Winter, Cassandra — University of Washington
- Study coordinator: Winter, Cassandra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.