Understanding how T cells divide to create different types of immune cells
Asymmetric cell division for fate commitment of human T cells
This study is looking at how T cells, which are important for fighting diseases, divide in a way that helps them become different types of cells, and it's aimed at improving treatments that use these immune cells to help patients feel better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11044178 on NIH RePORTER |
What this research studies
This research investigates how human T cells use a process called asymmetric cell division to create daughter cells with different functions. By employing advanced techniques such as multicolor flow cytometry and single-cell RNA sequencing, the study aims to identify the factors that influence T cell differentiation and persistence. The goal is to enhance T cell immunotherapy by optimizing how these immune cells are generated and maintained in the body. Patients may benefit from improved therapies that harness the power of their own immune cells to fight diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals undergoing T cell therapy or those with conditions that could be treated with enhanced T cell responses.
Not a fit: Patients with conditions unrelated to T cell function or those not eligible for T cell therapies may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective T cell therapies for cancer and other diseases.
How similar studies have performed: Previous research has shown promising results in understanding T cell behavior and improving immunotherapy approaches, indicating that this area of study has potential for significant advancements.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Ellebrecht, Christoph Thomas — University of Pennsylvania
- Study coordinator: Ellebrecht, Christoph Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.