Understanding how T cells die to maintain a balanced immune response
Temporal and Metabolic Regulation of Restimulation-Induced Cell Death (RICD) in Human T Cells
This study is looking at how certain signals tell T cells, which are important for a healthy immune system, when to die after being activated too many times, and it’s aimed at helping people with immune disorders by finding better ways to treat autoimmune diseases and immune deficiencies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project ID | NIH-11000291 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate the death of T cells, which are crucial for maintaining a healthy immune system. It focuses on a process called restimulation-induced cell death (RICD), where activated T cells are instructed to die after repeated activation to prevent excessive immune responses. By studying patients with immune disorders, the research aims to uncover the biochemical signals that dictate whether T cells survive or die, which could lead to better understanding and treatment of autoimmune diseases and immune deficiencies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune disorders or those with known defects in T cell regulation.
Not a fit: Patients with stable immune conditions or those not affected by autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help restore balance in the immune system for patients with autoimmune diseases.
How similar studies have performed: Previous research has shown success in understanding immune regulation through similar biochemical approaches, indicating potential for impactful findings in this area.
Where this research is happening
Bethesda, United States
- Henry M. Jackson Fdn for the Adv Mil/med — Bethesda, United States (Active)
Researchers
- Principal investigator: Snow, Andrew L — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Snow, Andrew L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.