Understanding how T cells develop and function in tissues
Regulation of T cell memory in tissue immunity
This study is looking at how certain immune cells, called tissue-resident memory T cells, develop and stay in our tissues to help protect us from infections and keep our bodies healthy, with the hope of finding new ways to treat infections and cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11058773 on NIH RePORTER |
What this research studies
This research investigates the development and function of tissue-resident memory T cells (TRM), which play a vital role in protecting the body from infections and maintaining tissue health. The study aims to uncover the environmental signals and metabolic processes that influence how T cells become TRM and how they are retained in specific tissues. Using advanced techniques like CRISPR screening, researchers will explore the genetic and metabolic factors that affect TRM formation, potentially leading to new therapeutic strategies for infectious diseases and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with infections or cancers where T cell responses are critical for treatment.
Not a fit: Patients with conditions unrelated to T cell function or those who do not have active infections or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for infections and cancers by enhancing the body's immune response through better understanding of T cell memory.
How similar studies have performed: Other research has shown promise in understanding T cell memory and its implications for immunity, suggesting that this approach could yield valuable insights.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Chi, Hongbo — St. Jude Children's Research Hospital
- Study coordinator: Chi, Hongbo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.