Understanding how T cells control cytomegalovirus and immune suppression in tissues
T cell control of MCMV and tissue-localized immune suppression
This study is looking at how certain immune cells help fight off cytomegalovirus (CMV) infections in the nose and salivary glands, using a mouse model to find ways to create better vaccines or treatments to stop the virus from spreading, especially for pregnant women.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10794397 on NIH RePORTER |
What this research studies
This research investigates the role of T cells in controlling cytomegalovirus (CMV) infections, particularly focusing on how the immune system functions in specific tissues like the nasal mucosa and salivary glands. By studying a mouse model that mimics human CMV infection, the researchers aim to uncover the mechanisms that allow the virus to persist and spread in these areas. The goal is to identify pathways that could be targeted for developing vaccines or therapies to prevent CMV transmission, especially during pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women or women planning to become pregnant who are at risk of CMV infection.
Not a fit: Patients who are not pregnant or those who have already been infected with CMV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective strategies for preventing congenital CMV infections, reducing the incidence of birth defects associated with the virus.
How similar studies have performed: Previous research has shown promise in understanding immune responses to CMV, but this specific approach focusing on tissue-localized mechanisms is relatively novel.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Snyder, Christopher M — Thomas Jefferson University
- Study coordinator: Snyder, Christopher M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.