Understanding how T cells can be better activated to fight cancer
Transcriptional Control of T Cell Function
This study is looking at how T cells, which help fight cancer, can become tired and less effective because of constant signals from tumors, and the researchers are trying to find ways to boost these T cells so they can keep attacking cancer better, which could help patients getting special cell therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-11042221 on NIH RePORTER |
What this research studies
This research investigates how T cells, which are crucial for fighting cancer, become less effective due to chronic stimulation from tumors. The team has identified specific transcription factors that contribute to this reduced function and is exploring ways to modify T cells to enhance their anti-tumor activity. By focusing on the Nuclear Receptor Subfamily 4 Group A (NR4A) transcription factors, the researchers aim to develop T cells that can resist exhaustion and maintain their ability to attack cancer cells. This could lead to improved outcomes for patients receiving adoptive cell therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are undergoing or considering adoptive cell therapy.
Not a fit: Patients with non-cancerous conditions or those not eligible for T cell therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by enhancing the ability of T cells to fight tumors.
How similar studies have performed: Previous research has shown promise in enhancing T cell function through similar approaches, indicating potential for success in this area.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Scott-Browne, James — National Jewish Health
- Study coordinator: Scott-Browne, James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.